Total nasal symptom score after nasal provocations improved by 42% in the verum versus 13% in the placebo group. Daily symptoms, medications, pollen concentrations and well-being were recorded by an eHealth application.

Prior and after dietary supplementation, participants were nasally challenged, and their blood was analyzed for immune and iron parameters. In a randomized, double-blind placebo-controlled pilot study, grass- and/or birch pollen allergic women (n=51) were supplemented with holoBLG (verum) or placebo lozenges over 6 months. The clinical efficacy of a FSMP (food for special medical purposes) lozenge containing beta-lactoglobulin with iron, polyphenols, retinoic acid, and zinc (holoBLG lozenge) were assessed in allergic women. Previously micronutrients were selectively delivered to immune cells with beta-lactoglobulin as carrier (holoBLG), resulting in immune resilience and allergy prevention. Within a treatment, means without a common letter differ, P, 0.05.įunctional iron deficiency facilitates allergy development and amplifies the symptom burden in allergy sufferers. (C ) Phagocytosis of zymosan expressed as number of cells with ingested particles. Results are means 6 SEM experiments with HBSS: Ctl, n ¼ 9 WPE 1 and 5 mg/L, n ¼ 8 WPE 10 mg/L, n ¼ 6 WPE 25, 50, and 100 mg/L, n ¼ 4 experiments with fMLP: Ctl and WPE 1 mg/L, n ¼ 13 WPE 5 mg/L, n ¼ 7 WPE 10 mg/L, n ¼ 9 WPE 25, 50, and 100 mg/L, n ¼ 3. (B) Chemotaxis was evaluated in response to fMLP or HBSS. (A) Neutrophils were then incubated with fMLP or with vehicle. Cells were preincubated in the incubation medium alone (Ctl) or with WPE for 24 h. FIGURE 2 WPE increases MPO release, chemotaxis, and phagocytosis by neutrophils. Within a treatment, means without a common letter differ, P, 0.05.

Values are means 6 SEM, n ¼ 6 means of duplicates. Superoxide production was subsequently measured in the absence (WPE alone) or in the presence of fMLP. WPE primes the production of superoxide anions by human blood neutrophils.

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